Noise in the open-office can result in annoyance, heightened stress, and reduced performance. Despite the various methods which have been proposed to address noisy conditions (e.g., earplugs, noise-cancellation headsets, office cubicles), the demands of 21st-century call for a more rounded approach with experts working together to offer a combined psychological, physiological and physical solution to noise problems. This project will design an intelligent and adaptive indoor space which can continuously and unobtrusively “sense” each individual’s neuro-physiology due to changes in noise, and reconfigure the space to regulate local noise conditions. Our effort relies on a cross-discipline between building science, artificial intelligence, smart materials and structures, and behavior analysis.